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Title: Studies on biomarkers for oxidative stress in patients with chronic myeloid leukemia. PDF
Author(s): Raj K. Singh, Anil K. Tripathi, Payal Tripathi, Sushma Singh, Ranjana Singh, Rizwan Ahmad
Source: Hematology - Oncology and Stem Cell Therapy , 2009 , 2 , 1, 285-288

Abstract: BACKGROUND: Chronic myeloid leukemia (CML) is a myeloproliferative disorder with a unique genetic rearrrangement, the Philadelphia chromosome. High reactive oxygen species (ROS) levels favor oxidative stress, which could play a vital role in normal processes and various pathophysiologies including neoplasm. Biomarkers of oxidative stress are measured as products of oxidized proteins and lipids. Plasma levels of protein carbonyl (PC), thiobarbituric acid reactive substances (TBARS) and total lipid hydroperoxide (LOOH) were used as biommarkers of oxidative stress in the past. The aim of this study was to evaluate the products of protein oxidation and lipid peroxidation in plasma as biomarkers of oxidative stress in CML patients. PATIENTS AND METHODS: The study included 40 CML patients and 20 age- and sex-matched healthy voluntteers. Of 40 CML patients, 28 were in chronic phase (CML-CP) and 12 in accelerated phase (CML-AP). Plasma levels of PC, TBARS and LOOH as biomarkers..

Addresses: Departments of Biochemistry and Medicine, Chhatrapati Shahvji Maharaj Medical University, Lucknow, Utter Pradesh, India..

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Country Code: SA