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Title: A retrospective comparison of allogeneic peripheral blood stem cell versus bone marrow transplantation. PDF
Author(s): Henrique Bittencourt, Monalisa Lopes, Antonio Vaz de Macedo, Elen Rose Teixeira, Gabriel Gomes Sabido Gomes, Galileu Galilei Ferreira, Leandro Amaral, Priscila Soares, Mônica Vieira, Luci Maria Dusse
Source: Hematology - Oncology and Stem Cell Therapy , 2009 , 2 , 1, 272-277

Abstract: BACKGROUND AND OBJECTIVES: Disease evolution depends in part on the source of transplanted cells. Therefore, we compared outcomes after allogeneic bone marrow (BM) and peripheral blood stem cell (PBSC) transplantation in patients who underwent transplant at Hospital das Clinicas of the Federal University of Minas Gerais, Brazil. PATIENTS AND METHODS: We studied 364 patients who received allogeneic BM (n=142) or PBSC transplanttation (n=222) between July 1995 and May 2005. The median age of the patients was 31 years (range, 3.1-58 years). Chronic myeloid leukemia was the predominant diagnosis (41.2%). A conditioning regimen with cycclosphosphamide and busulfan was used in 79.4% (n=289) and graft-versus-host disease (GVHD) prophylaxis was cyclosporine/methotrexate in 95.9% (n=349) of cases. RESULTS: The patients in the PBSC group had faster neutrophil (P<.001) and platelet engraftment (P=.03) but increased rates of acute GVHD (P<.001) vs. those in the BM group. There was no significant difference between the groups in chronic GVHD,..

Addresses: aInternal Medicine Department, b Hematopoietic Stem Cell Transplantation Unit/Hematology Division, cDepartment of Clinical and Toxicological Analysis, dSchool of Medicine, Universidade Federal de Minas Gerais, Minas Gerais, Brazil..

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Country Code: SA