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Title: The association of TGF-?1, angiotensin II and oxidative stress with diabetic nephropathy in type 2 diabetic patients
Author(s): HO El-mesallamy 1, MZ Gad2 and AM Sallam1
Source: International Journal of Diabetes and Metabolism , 2008 , Vol 16 , Issue 2, 62 ; 68

Abstract: Diabetic nephropathy (DN) is a severe complication of diabetes which may progress to end-stage renal disease (ESRD). Chronic hyperglycemia is considered as the major initiator of DN, either by creation of oxidative stress or by induction of growth factors and cytokines. Moreover, dyslipidemia plays a role in DN progression. The aim of our study was to examine the changes in lipid profile, malondialdehyde (MDA), transforming growth factor-?1 (TGF-?1) and angiotensin II (Ang II) levels in type 2 diabetic patients associated with kidney disease. Diabetic microalbuminuric (n=25) and macroalbuminuric (n=15) patients showed significantly higher levels of blood glucose, glycated hemoglobin (HbA1c), triglycerides (TG), total cholesterol (TC), MDA, TGF-?1 and Ang II than either diabetic normoalbuminuric (n=14) or control (n=16) subjects. In the microalbuminuric and macroalbuminuric diabetic groups, albumin excretion rate (AER) was positively correlated with MDA (r=0.448, p<0.01), TGF-?1 (r=0.81, p<0.01) and Ang II (r=0.772, p<0.01). Additionally, MDA correlated with TGF-?1 (r=0.625, p<0.01) and Ang II (r=0.428, p<0.01). In conclusion, dyslipidemia, oxidative stress, and increased TGF-?1 and Ang II are associated with DN in type 2 diabetic patients...

Addresses: Department of Biochemistry, Faculty of Pharmacy, Ain Shams University1, Department of Biochemistry, Faculty of Pharmacy, The German University of Cairo2, Cairo, Egypt..

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Country Code: AE